Adenine Methylation: New Epigenetic Marker of DNA and mRNA
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چکیده
منابع مشابه
DNA methylation patterns and epigenetic memory.
The character of a cell is defined by its constituent proteins, which are the result of specific patterns of gene expression. Crucial determinants of gene expression patterns are DNA-binding transcription factors that choose genes for transcriptional activation or repression by recognizing the sequence of DNA bases in their promoter regions. Interaction of these factors with their cognate seque...
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Cite this article: Yamada N, Yonezawa S (2013) Understanding Epigenetic Status: DNA Methylation and Cancer. J Cancer Biol Res 1(2): 1008. *Corresponding author Norishige Yamada, Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan, Tel: +81-99275-5270; Fax: +81-99-265-7235; E-mail: ya...
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During embryonic development, cell type-specific transcription factors promote cell identities, while epigenetic modifications are thought to contribute to maintain these cell fates. Our understanding of how genetic and epigenetic modes of regulation work together to establish and maintain cellular identity is still limited, however. Here, we show that DNA methyltransferase 3bb.1 (dnmt3bb.1) is...
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Why some patients develop limband life-saving collaterals but others do not constitutes one of the great challenges that face patients with peripheral vascular and coronary artery disease. A longstanding goal in vascular disease is the establishment of therapies that enhance angiogenesis in compromised tissue beds. To achieve this goal, however, it is essential to define and understand the unde...
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DNA methylation, an epigenetic mechanism is claimed to play essential roles in development, aging and disease over the past few decades. Cytosines (C) were known to exist in two functional states: unmethylated or methylated (5mC) in the mammalian genome for a very long time. However, the mechanisms controlling 5mC dynamics remain undefined. Recent studies of genomic DNA on human and mouse brain...
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ژورنال
عنوان ژورنال: Molecular Plant
سال: 2018
ISSN: 1674-2052
DOI: 10.1016/j.molp.2018.08.001